Naringenin protects against scopolamineinduced dementia. Abdul kalam technical university, lucknow, uttar pradesh. Study on evaluation of nootropic effect of piracetam and. Pdf scopolamineinduced amnesia can be prevented by heat. Pdf in the present study we investigated the antiamnesic activity of vitex negundo in scopolamine induced amnesia in rats. The present study aimed to evaluate the preventive effects of highbush blueberry vaccinium corymbosum l. Amelioration of scopolamineinduced learning and memory. Evaluation of antiamnesic activity of salvia multicaulis. The present study aimed to evaluate whether salvia multicaulis essential oil 1% and 3% administered for 21 days attenuates cognitive deficits and exhibits anxiolytic and antidepressantprofile in the scopolamine induced amnesia in rats. Dementia was induced at the end of the treatment period by a single injection of scopolamine 20 mgkg.
Abstractalzheimers disease is the most common neurodegenerative disease and this disease. Study was undertaken to evaluate the nootropic effects of piracetam and modafinil in scopolamine induced amnesia in rats. Treadmill exercise ameliorates shortterm memory disturbance. Mar 31, 2014 the mean perimeter of the blood vessels in the hippocampal dentate gyrus was 1,4608. Antiamnesic effect of leea indica extract in scopolamine. The animal model of scopolamine scopinduced amnesia is widely. The standardized aqueous extract of crataeva nurvala aecn was freshly dissolved in distilled water and administered orally to rats at the dose of 500 mgkg for evaluation of its effects against scopolamine 3 y. Molecular modeling of in vitro and in vivo approaches razvan stefan boiangiu 1, ion brinza 1, monica hancianu 2, ilkay erdogan orhan 3, gokcen eren 4, elife gunduz 5, halis ertas 5, lucian hritcu 1, and oana cioanca 2. On the other hand, the scopolamineinduced amnesia cannot be reversed by posttreatment with heat shock.
To investigate the potential role of ramipril and losartan in preventing scopolamine induced memory impairment in rats. Each rat was placed individually in the actophotometer for 5 min and the basal activity score was obtained. Behavioral, biochemical, and molecular evidence beenita saikia 1, chandana c barua 1, jadav sarma 1, prakash haloi 2, sarojini m tamuli 3, dhruba j kalita 4, arundhati purkayastha 5, achinta g barua 6. Antiamnesic activity of vitex negundo in scopolamine. To evaluate the effect of lyophilized hydroalcoholic extract of bf leaves bfle at 100, 200 and 400mgkg, p. Pdf memory enhancing activity of momordica charantia by. Zanthoxylum alatum ameliorates scopolamineinduced amnesia. To investigate the potential role of ramipril and losartan in preventing scopolamineinduced memory impairment in rats. Hence, these findings suggest that heat shock pretreatment has a protective, rather than therapeutic, effect on the scopolamineinduced amnesia. Scopolamineinduced amnesia can be prevented by heat shock pretreatment in rats. The polygalae radix extract bt11 has been shown to have memoryenhancing effects in rats with scopolamineinduced amnesia 12 and cognitionimproving effects in two randomized, doubleblind. In the acute scopolamine induced memory impairment in rats as depicted in figure 3 a1, the percentage of recognition index for the positive control donepezil 1 mgkg, negative control scopolamine 1 mgkg and the os extract treated groups, were found to be unchanged, indicating that the acute scopolamine induced memory was not impaired f. Amnesia was induced by scopolamine injection 3 mg kg, i. In the acute scopolamineinduced memory impairment in rats as depicted in figure 3 a1, the percentage of recognition index for the positive control donepezil 1 mgkg, negative control scopolamine 1 mgkg and the os extract treated groups, were found to be unchanged, indicating that the acute scopolamineinduced memory was not impaired f.
Evaluation of cucurbita maxima extract against scopolamine. All groups except the control group received scopolamine. Etoacapv were found to demonstrate potent acetylcholinesterase ache inhibition in vitro. Memory impairment was induced by scopolamine 4 mgkg, i. Scopolamineinduced amnesia is a very well recognized animal model of memory dysfunction, widely used to test potential drugs of anti. Scopolamine was administered at a dose of 3 mg kg 1, i. Hence, these findings suggest that heat shock pretreatment has a protective, rather than therapeutic, effect on the scopolamine induced amnesia. The present study was undertaken to investigate the effect of momordica charantia on cognitive functions, total cholesterol levels and cholinesterase che activity in scopolamineinduced amnesia in rats. The present study investigated the potential of leea indica extract in amnesia of alzheimers type induced in by scopolamine rats. Cognitive and memory enhancing activities of tannins on scopolamineinduced learning and memory impairment in rats the precise pathological mechanism of ad is unknown, but amyloidrich plaques are known neuropathologic hallmark, and acetylcholine esterase ache inhibitor is generally used as primary therapeutic agents for neurodegenerative. Antiamnesic and neuroprotective effects of low dose of. The retention of the passive avoidance response is not affected by phosphatidylserine given alone. Moringa oleifera seed extract alleviates scopolamine.
Amnesia is one of the major complications associated with memory loss in the patents of neurodegenerative disease like alzheimers disease ad. Cyperus rotundus cr and psoralea corylifolia pcon the scopolamine scop. Neuroprotective effect and molecular mechanism of 6. Male adult wistar rats were administered scopolamine 1 mgkg body weight, i. In this study, ethyl acetate parts of aqueous extracts from p. The rats were fed with standard rat chow pellet and water ad libitum. The therapeutic effect of crocin on scopolamine induced. Amnesia induced by scopolamine has been widely used to understand the biochemical and behavioral. Effects of atropine on discrimination learning in the rat. Treadmill exercise ameliorates disturbance of spatial. The present study was undertaken to investigate the effect of momordica charantia on cognitive functions, total cholesterol levels and cholinesterase che activity in scopolamine induced amnesia in rats.
Scopolamineinduced amnesia can be prevented by heat shock. Cognitive facilitation and antioxidant effects of an. Antiamnesic effect of aqueous extract of crataeva nurvala. It is believed that neurophysiological effects of sesame oil on the learning process may be due to its antioxidant effects15. The mice were randomly divided into 4 groups n10 in each group. The present study aimed to evaluate whether salvia multicaulis essential oil 1% and 3% administered for 21 days attenuates cognitive deficits and exhibits anxiolytic and antidepressantprofile in the scopolamineinduced amnesia in rats. Scopolamineinduced cognitive deficit in young volunteers is similar to that. Abstract cucurbita maxima cm seed oil is commonly used in indian folk medicine to treat various ailments. The mo was administered by inhalation to rats once daily for 21 days, while sco 0. Genistein ameliorates scopolamineinduced amnesia in mice. The observed neuroprotective and improved cognitive could be due to the synergistic effect of the drugs by decreasing the ache level. Effect of rosuvastatin on learning and memory in scopolamine. Memory impairment was induced in male wistar rats by administration of scopolamine 1 mgkg intraperitoneally.
This article is from journal of exercise rehabilitation, volume 10. Scopolamine 2 mgkg ip and propranolol 55 mgkg ip, given before a single learning trial, reduce retention of a passive avoidance response in rats. Jul 28, 2000 the ameliorating effects of the cognitive. Wistar rats 180200 g were trained on active avoidance task. In the present study, we assessed the neuropharmacological effects of 70% ethanolic m. In this study, sco 1 mgkg, intraperitoneal injection was used to induce amnesia. A study on scopolamine amnesic mice bioline international. The normal control group received normal saline and test group animals were pretreated orally with quercetin 25. Naringenin protects against scopolamineinduced dementia in rats. Essential oil mix on scopolamineinduced amnesia in rats. Evaluation of neuroprotective effect of quercetin with.
The present study concludes pretreatment with quercetin potentiates the action of donepezil in scopolamineinduced amnesia in rats. After injection of scopolamine, each rat was placed in the shuttle box and. Molecules free fulltext cognitive facilitation and. Frontiers ethanolic extract of orthosiphon stamineus. We have investigated the neuroprotective and memory enhancing effect of 6gingerol gin, a pungent ingredient of ginger, using an animal model of amnesia. Behavioral, biochemical, and molecular evidence beenita saikia 1, chandana c barua 1, jadav sarma 1, prakash haloi 2, sarojini m tamuli 3, dhruba j kalita 4, arundhati purkayastha 5, achinta g barua 6 1 department of pharmacology and toxicology, college of veterinary science, assam agricultural university. Effect of acidic oligosaccharide sugar chain on scopolamineinduced memory impairment in rats and its related mechanisms. In control group no drug was given and only diet and water were provided. Sixteen hours after heat shock treatment when hsp70 is induced in the frontal cortex, corpus striatum, hippocampus and hypothalamus, rats have a reduction in amnesia induced by scopolamine, a. Effects of moringa oleifera seed extract mse on scopolamineinduced memory impairments on the stepdown test. Ameliorating effect of lyophilized extract of butea.
Decursin from angelica gigas mitigates amnesia induced by. Antiamnesic effect of the bfle was evaluated using morris water maze and object recognition. The present study investigated the capability of an essential oil mix mo. Zanthoxylum alatum ameliorates scopolamineinduced amnesia in. Since, scopolamineinduced memory impairment is associated with brain oxidative stress and oxidative stress is one of. Antiamnesic activity of vitex negundo in scopolamine induced. The objective of this study was to evaluate the neuroprotective effect of quercetin with donepezil in scopolamineinduced amnesia in rats.
Protective effect of nycthanthes arbortristis on scopolamine induced amnesia in rats a behavioural and biochemical approach sonakshi antal, vrish dhwaj ashwlayan and anuj kumar pharmaceutical technology, meerut institute of engineering and technology, meerut, india, dr. Zanthoxylum alatum ameliorates scopolamine induced amnesia in rats. Effect of scopolaminebased amnesia on the number of astrocytes. We have investigated the effect of cm seed oil on memory impairment induced by scopolamine in rats. Scopolamine, an anticholinergic drug, causes amnesia in humans and also impairs.
Zanthoxylum alatum ameliorates scopolamineinduced amnesia in rats. It has been shown that the reduction in acetylcholinesterase ache activity which reduces. Enduring amnesia induced by icv scopolamine is reversed by. Apr 24, 2018 the extract of moringa oleifera seeds has been shown to possess various pharmacological properties. Experiments were carried out to determine the cognitive and memory enhancing actions of these tannins on passiveactive avoidance task and water maze task.
Kshirsagar1 1sudhakarrao naik institute of pharmacy, pusad,m. The therapeutic effect of crocin on scopolamine induced retrograde amnesia in male rats authors seid ershad nedaei 1. Scopolamine induced amnesia is a very well recognized animal model of memory dysfunction, widely used to test potential drugs of anti. The cognitive and memory functions of the rats were assessed half an hour after the administration of scopolamine 12. Louis, mo, usa intraperitoneally once a day 30 min before the treadmill exercises for 5 consecutive. Scopolamine induced amnesia can be prevented by heat shock pretreatment in rats. On the other hand, the scopolamine induced amnesia cannot be reversed by posttreatment with heat shock. Moringa oleifera seed extract alleviates scopolamineinduced. To study acquision, consolidation and recall stages of memory, aterials and methods. Phosphatidylserine, 3060 mgkg ip, antagonizes the amnesic effect of scopolamine but not that of propranolol. We studied effects of these three tannins on cognition and memory enhancing in scopolamine induced amnesia rat model. Five groups of adult male wistar rats 12 months old weighing 180200 g n 6 were used. Each column, center line in the column and the bars. Cognitive improving effects by highbush blueberry vaccinium.
Memory impairment induced by intracerebroventricular icv injection of scopolamine hydrochloride 10. In the present study we investigated the antiamnesic activity of vitex negundo in scopolamine induced amnesia in rats. Icr mice were orally administered donepezil 5 mgkg, blueberry extract 120 mgkg, and bv. Polygalasaponin xxxii, a triterpenoid saponin from. Icr mice were orally administered donepezil 5 mgkg, blueberry extract 120 mgkg, and bv 120 mgkg for 7 days. Each animal received session of 15 trials with inter trial duration of 15 s for 5 days. Aim of the study was to evaluate the antiamnesic effects of crataeva nurvala stem bark in scopolamine induced amnesia in rats. International journal of pharmtech research coden usa. Ameliorating effect of lyophilized extract of butea frondosa. Brain damage due to oxidative stress can induce impairment in learning and memory abilities.
631 289 1447 1522 869 161 213 247 434 408 408 679 825 333 968 1269 817 972 1591 1316 718 816 296 852 441 313 1201 384 587 1133 747